Pioneering Electrochemical Purification Solutions

Creating a world with affordable medicine

We're turning breakthrough materials innovations into cutting-edge purification solutions that transforms biomanufacturing.

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Electrification and Digitalization of Purification

The Nyctea purification platform

Lower cost of goods for biologics

Electrification of purification

Removes the need to use chemicals to elute from resin

Digitalizing purification

Converts your resin to an in-situ PAT sensor immediate access to purification data enabling accelerated automation

The Nyctea Advantage

How our breakthrough technology for purification compares to conventional chromatography

CONVENTIONAL CHROMATOGRAPHY

PRODUCTION COST: $6M

NYCTEA™ PURIFICATION

POTENTIAL COST REDUCTION: -45 to 90%

Gentle purification = Higher yield

CONVENTIONAL CHROMATOGRAPHY

CONSUMABLES & WATER: 8 tons

NYCTEA™ PURIFICATION

POTENTIAL CONSUMPTION REDUCTION: -60%

Replace chemicals & Reduce water use

CONVENTIONAL CHROMATOGRAPHY

PRODUCTION TIME: 18 MO

NYCTEA™ PURIFICATION

POTENTIAL REDUCED TIME: 4.5 MO

Faster cycles, Fewer steps

PRODUCTION COST

$6M

POTENTIAL COST REDUCTION

-45 to 90%

Gentle purification = Higher yield

CONSUMABLES & WATER

8 tons

POTENTIAL CONSUMPTION REDUCTION

-60%

Replace chemicals & Reduce water use

PRODUCTION TIME

18 MO

POTENTIAL REDUCED TIME

4.5 MO

Faster cycles, Fewer steps

Chromatography Example

Figures displayed are characteristic of what is required investment in terms of production cost, materials, and time for producing the required amounts of a monoclonal antibody therapy in a pre-clinical toxicity study.

Nyctea™ Example

Boost the yield by up to 600% for next generation biologics under development to significantly increase your chance of success.

Chromatography Example

Similar values for Cost of goods (COGs), Process Mass Intensity (PMI) and time apply for pre-clinical peptide, oligonucleotide, and gene therapies under development

Nyctea™ Example

Boost the yield by up to 600% for next generation biologics under development to significantly increase your chance of success.

Our Technology

Innovative solutions for the next generation of biopharmaceuticals

Electrically Switchable Polymer Brushes

Our proprietary technology uses innovative polyelectrolyte brush electrodes that can capture and release proteins with unprecedented efficiency.

Superior Purification Process

Our approach eliminates the need for harsh chemicals in purification, preserving the integrity of biomolecules while reducing environmental impact.

Scientifically Validated

Our technology is backed by peer-reviewed publications and extensive research in the field of biomolecular purification.

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How does it work?

Conventional Chromatography

Elute by switching the solution

Interior surface of a chromatography column

Requires solution replacement
Elution chemical may negatively affect product

Electrochemical Purification

Elute by switching the surface

Interior surface of a Nyctea electrode device

Electro-responsive polymer coating
Instantaneous release in neutral buffer

Applications of Nyctea^TM Purification

Discover how our breakthrough technology can be used to purify a broad range of different modalities

Next gen mAbs

ADCs, bispecifics, fusion, radiotherapeutics

Oligonucleotide therapeutics

siRNA, ASO, mRNA, psDNA

Gene therapy

Viral vectors, AAVs, LVs, LNPs, exosomes

Cell therapy

Handling and isolation bead-free

Protein, peptides & enzymes

Electrochemical ion-exchange

Post & pre-processing

Up-concentration, buffer exchange, de-salting

About Nyctea Technologies

We're a team of scientists, engineers, and innovators dedicated to solving some of the world's most pressing challenges in healthcare through biotechnology.